Your Epigenetic Clock
Measure how fast you’re aging, how your organ systems compare to your calendar age, and how your lifestyle is shaping your gene expression today — then let a physician scientist turn that data into a personalized plan.
Powered by TruDiagnostic™ — the world’s largest epigenetic methylation database, built with Yale, Duke, Columbia, and Harvard
Why Epigenetics — Not Just Genetics
Your DNA is fixed at birth. But how your genes are expressed changes every day based on your diet, stress, sleep, exercise, and environment. Epigenetic testing measures that dynamic layer — and unlike genetic testing, you can retest to track what’s actually working.
Dynamic & Modifiable
DNA methylation patterns shift in response to lifestyle interventions in weeks to months. Test, intervene, retest — and see the impact in hard numbers, not just how you feel.
Beats Standard Labs
Where a blood draw measures CRP at one moment, epigenetic biomarker proxies reflect inflammation averaged over weeks — giving a more stable, more predictive read on chronic disease risk.
Physician-Interpreted
Consumer epigenetic reports leave you with 180+ data points and no context. Dr. Kilgore integrates your results with your bloodwork, genetics, and wearables to build a clinical strategy.
The Four-Layer Data Integration Framework
Every layer tells a different part of the story. Epigenetics is Layer 2 — the missing bridge between your DNA and your bloodwork.
Genetics (DNA)
Your permanent blueprint. What you inherited. Doesn’t change across your lifetime — so you test once, interpret forever. See FitnessGenes →
Epigenetics YOU ARE HERE
How your genes are expressed right now. TruDiagnostic’s OMICmAge™, SYMPHONYAge™, and DunedinPACE™ reveal your biological age, organ-specific aging, and the speed at which you’re aging today — all modifiable with lifestyle.
Biomarkers
Your real-time blood chemistry. Analyzed through 30+ AI-powered calculators on drpaulkilgore.com — from inflammation and lipids to kidney, liver, and metabolic health.
Wearables
Continuous data from Oura, WHOOP, Apple Watch, and CGMs. Heart rate variability, sleep architecture, and glucose responses feed back into the system daily.
All four layers integrated = precision health. Any one alone = a partial picture.
What the Research Actually Shows
Epigenetic testing is not biohacker hype. It is built on peer-reviewed research from Yale, Duke, Columbia, Harvard, and NIH-funded labs. Here is what the science says — in plain language.
What is epigenetics?
Epigenetics is the study of how your environment and lifestyle change the way your genes work — without altering the underlying DNA sequence. Think of it like a light switch: your genes can be turned on or off depending on diet, stress, sleep, toxin exposure, and exercise. The most well-studied epigenetic change is DNA methylation — small chemical tags that attach to your DNA and change how a gene is expressed. That is the signal TruDiagnostic measures.
Aging — and the related changes in gene expression — don’t occur at the same rate for everyone. By studying the patterns of epigenetic change, we can understand how to delay age-related disease and optimize healthspan.
Epigenetic Biomarker Proxies (EBPs)
TruDiagnostic partnered with Harvard to develop more than 1,670 Epigenetic Biomarker Proxies — methylation-based estimates of biomarker levels. Unlike a standard blood draw that captures one moment in time, EBPs reflect biomarker averages over weeks or months. That makes them more stable, more predictive, and less influenced by what you ate for breakfast.
Here is how DNAm CRP (a methylation-based inflammation marker) compares to standard CRP blood testing:
| Criteria | Standard CRP | DNAm CRP |
|---|---|---|
| Cognitive impairment prediction | No significant association | Strong correlation ✓ |
| Precision (ICC value) | 0.72 | 0.82 ✓ |
| Reflects long-term health | Snapshot only | Weeks to months ✓ |
| Captures lifestyle impact | No | Yes — diet, smoking, stress ✓ |
Zhang Y et al. Clin Epigenetics 2022 • PMC8665430
Methylation Risk Scores vs. Polygenic Risk Scores
You may have heard of Polygenic Risk Scores (PRS) from consumer DNA tests. PRS tells you your genetic predisposition at birth — and it never changes. Methylation Risk Scores (MRS) are different: they reflect how your genes are being expressed right now, and they shift in response to lifestyle.
Static. Inherited.
- Fixed at birth
- Based on SNPs in your DNA
- Cannot be modified
- One-and-done test
Dynamic. Actionable.
- Changes over time
- Based on DNA methylation patterns
- Responds to lifestyle
- Retest to track progress
This is why epigenetic testing is the future of clinical medicine: you can see what is happening in your body today, intervene, and measure whether the intervention is working.
Built on Research From the World’s Top Institutions
TruDiagnostic’s algorithms are not proprietary black boxes. Each is developed in partnership with a leading academic research institution and validated through peer-reviewed publications.
Organ-system-specific epigenetic aging algorithm. Evaluates how your brain, heart, liver, kidney, and immune system are aging independently.
Measures the rate at which your body is aging right now. Ideal for tracking the effect of lifestyle interventions over time.
Epigenetic Biomarker Proxies covering nutrition, inflammation, hormones, and metabolic pathways — from a single drop of blood.
Next-generation model for how DNA methylation shifts over time. Federally funded research into predicting chronic disease onset before symptoms appear.
CLIA-certified laboratory • Largest private DNA methylation database in the world • 100,000+ samples tested
Which Epigenetic Test Is Right for You?
Answer three quick questions and we’ll recommend the right TruDiagnostic test for your health goals — plus send you a personalized guide to understanding your results.
What matters most to you right now?
Have you done epigenetic testing before?
Which approach fits you best?
We’ve Found Your Match
Enter your name and email to receive your personalized epigenetic guide plus next steps:
Your information is never sold. Privacy policy →
Your Guide Is On Its Way
Check your inbox in the next 2 minutes (and spam folder just in case). Your personalized guide breaks down exactly what your recommended test measures and how to prepare.
Preferred Provider Pricing • Physician-Interpreted • Four-Layer Health Integration
From Order to Insights in Four Weeks
No blood draw. No lab visit. No prescription required. Everything you need arrives at your door, and you ship it back with a prepaid label.
Choose Your Test
Reserve your TruAge, TruHealth, or Bundle kit below. Subscriptions ship four kits per year for quarterly retesting at the best per-kit price.
Collect at Home
A collection kit ships to your door with everything included. Use the pain-free lancet for a finger-prick blood sample — five minutes, no appointment needed.
Ship & Analyze
Send your sample back with the prepaid FedEx label. TruDiagnostic’s CLIA-certified lab runs your methylation analysis across 100,000+ DNA sites.
Receive Your Results
Your personalized report arrives online within 3 to 4 weeks of lab receipt. Add a physician interpretation session to integrate your data with the rest of your health picture.
Reserve Your Epigenetic Test
Three ways to start. All kits include free domestic shipping and access to the TruDiagnostic member portal. Subscriptions save you up to 14% per kit for quarterly testing.
- Biological Age (OMICmAge™)
- Pace of Aging (DunedinPACE™)
- 11 Organ System Ages
- Telomere length
- Immune cell profile
- Smoking & alcohol impact
- 75+ longevity biomarkers
- Everything in TruAge™
- Everything in TruHealth™
- 180+ biomarkers total
- Best for quarterly retesting
- Most complete data set
- Physician interpretation recommended
- Ideal for serious longevity tracking
- 105+ biomarkers analyzed
- Vitamins A, B-complex, C, D, E
- Amino acids & antioxidants
- Inflammation (CRP, IL-6)
- Brain & memory markers
- Heavy metals & PFAS
- Gut & metabolic markers
All kits processed through TruDiagnostic’s CLIA-certified laboratory in Lexington, KY • Free domestic shipping • HSA/FSA eligible • No prescription required
$725 of Data Deserves $225 of Context
180+ biomarkers and three epigenetic age scores is a lot of information to interpret on your own. Dr. Kilgore personally walks you through your results in a 60-minute session, integrating your epigenetic data with your bloodwork, genetics, and wearables to build a clinical strategy.
- 60-minute video session with Dr. Kilgore
- Your TruDiagnostic results contextualized
- Integration with your blood chemistry
- Prioritized action plan you can actually follow
- Written summary delivered within 48 hours
HSA/FSA eligible • Scheduled via Calendly after booking
Frequently Asked Questions
If you don’t see your question answered here, email [email protected] directly.
Consumer DNA tests measure your genetics — the fixed blueprint you inherited at birth. TruDiagnostic measures your epigenetics — how your genes are being expressed right now based on your lifestyle, diet, stress, and environment. Epigenetic markers change over time; genetic markers do not. That is why TruDiagnostic tests are designed to be retaken every 3 to 12 months to track your progress, whereas DNA tests are one-and-done.
Neither. TruDiagnostic kits use a simple at-home finger-prick that takes five minutes. No prescription is needed, no lab appointment required, and no blood draw. The kit ships to your door with everything included, and you return it with a prepaid FedEx label.
For active intervention tracking, quarterly (every 3 months) is ideal — that is what the 4-kit annual subscription is built for. If you are establishing a baseline and tracking long-term trends without major lifestyle changes, annual testing is sufficient. Meaningful epigenetic shifts typically require at least 8 to 12 weeks of sustained intervention before they appear in measurable methylation changes.
Results are typically available 3 to 4 weeks after the lab receives your sample. You will receive an email notification when your report is ready in the TruDiagnostic member portal. If you have added the physician interpretation session, Dr. Kilgore’s team will reach out to schedule once your report is available.
Yes. TruDiagnostic operates a CLIA-certified laboratory and complies with HIPAA and federal data protection standards. Your sample is de-identified during processing, your results are encrypted at rest and in transit, and your data is not sold to third parties. All physician sessions with Dr. Kilgore are conducted via HIPAA-compliant Zoom for Healthcare under a signed Business Associate Agreement.
Yes. Both TruDiagnostic test kits and Dr. Kilgore’s physician interpretation sessions ($225) are HSA and FSA eligible when paid with an HSA/FSA card. After your reservation is confirmed, we send ordering details that support HSA/FSA reimbursement. Insurance does not typically cover epigenetic testing at this time.
No. TruDiagnostic tests are health and wellness assessments, not FDA-approved diagnostic tests for specific diseases. They measure DNA methylation patterns that correlate with aging, nutritional status, inflammation, and other health markers — but they do not diagnose cancer, heart disease, or any other specific condition. Dr. Kilgore interprets your results in the context of your complete health picture including your bloodwork, history, and symptoms.
Reserving a kit through this page does not charge you. You will receive an email within one business day containing: (1) your preferred provider ordering link, (2) pricing confirmation, (3) your provider code, and (4) shipping timeline. You complete the purchase directly with TruDiagnostic using the provider pricing. If you have added a physician interpretation session, Dr. Kilgore’s team will contact you once your results are available to schedule.
Your Epigenetic Data Is Waiting
Biological age. Pace of aging. 180+ biomarkers. The most complete picture of how your body is actually aging — with a physician who can turn that data into a plan.
Educational Purpose Only
Information on this page is for educational purposes and does not constitute medical advice, diagnosis, or treatment. TruDiagnostic tests are health and wellness assessments, not FDA-approved diagnostic devices. Always consult a qualified physician about any health concerns.
Physician-Patient Relationship
Reserving a kit through this page does not establish a physician-patient relationship with Dr. Paul Kilgore or Quantitative Health LLC. A relationship is established only upon completion of a paid consultation and intake process. For medical emergencies, call 911.
Data & Privacy
TruDiagnostic operates a CLIA-certified lab and complies with HIPAA. Consultations with Dr. Kilgore use HIPAA-compliant Zoom for Healthcare under a signed Business Associate Agreement. Your data is never sold. Privacy policy →
Results & Outcomes
Individual results from epigenetic testing vary. Biological age, pace of aging, and biomarker changes depend on consistent lifestyle intervention, genetic factors, and time. No specific health outcome is guaranteed. Testimonials reflect individual experiences and are not representative.
